1629265-17-3
Chemical Structure
K-Ras G12C-IN-1
- CAS No.: 1629265-17-3
- Formula:C22H23Cl2N3O3
- Molecular Weight:448.34
IUPAC Name: 1-(4-((2',6-dichloro-4-methoxy-[1,1'-biphenyl]-3-yl)glycyl)piperazin-1-yl)prop-2-en-1-one
InChIKey: ZJWLFLPGQCYBSE-UHFFFAOYSA-N
SMILES: ClC(C=C(OC)C(NCC(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC=CC=C3Cl
Biological Activity: K-Ras G12C-IN-1 is an irreversible covalent KRAS G12C inhibitor. K-Ras G12C-IN-1 contains an electrophilic group that forms an irreversible covalent bond with Cys12 of mutant K-Ras. After covalent binding to Cys12, it locks Switch II in an inactive state and interferes with downstream Ras signaling. K-Ras G12C-IN-1 can be used in research related to pancreatic cancer, colon cancer, MYH-associated polyposis, colorectal cancer, and lung cancer[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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K-Ras G12C-IN-1 | 98.19% | K-Ras G12C-IN-1 is an irreversible covalent KRAS G12C inhibitor. K-Ras G12C-IN-1 contains an electrophilic group that forms an irreversible covalent bond with Cys12 of mutant K-Ras. After covalent binding to Cys12, it locks Switch II in an inactive state and interferes with downstream Ras signaling. K-Ras G12C-IN-1 can be used in research related to pancreatic cancer, colon cancer, MYH-associated polyposis, colorectal cancer, and lung cancer. | ||||||||||||||||||||
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