1631056-29-5
Chemical Structure
BJ-2302
- CAS No.: 1631056-29-5
- Formula:C9H10N2O2
- Molecular Weight:178.19
InChIKey: TTZDLIXBHFOMJL-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C1)C(C)=C(O)C(C)=N2
Biological Activity: BJ-2302 is a Src kinase inhibitor with an IC50 of 3.23 μM, and inhibits cathepsin S (CTSS) activity[1][2].BJ-2302 binds to Src, suppresses PI3K/AKT and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression[2][3].BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth[1][2][3].BJ-2302 does not induce cytotoxicity in normal breast epithelial cells[3].BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer[1][2][3].
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BJ-2302 | BJ-2302 is a Src kinase inhibitor with an IC50 of 3.23 μM, and inhibits cathepsin S (CTSS) activity.BJ-2302 binds to Src, suppresses PI3K/AKT and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression.BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth.BJ-2302 does not induce cytotoxicity in normal breast epithelial cells.BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer. | |||||||||||||||||||||
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References
- [1]. Yang SF, et al. Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy. J Pineal Res. 2020;68(1):e12615. [Content Brief]
- [2]. Liao M, et al. Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions. J Med Chem. 2021;64(5):2382-2418. [Content Brief]
- [3]. Gautam J, et al. Down-regulation of cathepsin S and matrix metalloproteinase-9 via Src, a non-receptor tyrosine kinase, suppresses triple-negative breast cancer growth and metastasis. Exp Mol Med. 2018;50(9):1-14. Published 2018 Sep 5. [Content Brief]
