1638193-48-2
1638193-48-2
Chemical Structure
Siremadlin succinate
Synonym(s): NVP-HDM201 succinate; HDM201 succinate
- CAS No.: 1638193-48-2
- Formula:C30H30Cl2N6O8
- Molecular Weight:673.50
InChIKey: WOEIHDWLQDGIAG-BDQAORGHSA-N
SMILES: OC(CCC(O)=O)=O.CC(N1C([C@H](C2=CC=C(C=C2)Cl)N3C4=CC(Cl)=CN(C)C4=O)=C(N=C1C5=CN=C(OC)N=C5OC)C3=O)C
Biological Activity: Siremadlin (NVP-HDM201) succinate is an MDM2 inhibitor and cell cycle regulator. Siremadlin succinate blocks the p53-binding pocket of MDM2, inhibits MDM2-mediated ubiquitination and degradation of p53, thereby activating the p53 pathway in p53 wild-type cells. Siremadlin succinate can be used in the research of cutaneous melanoma[1].
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Siremadlin succinate | Siremadlin (NVP-HDM201) succinate is an MDM2 inhibitor and cell cycle regulator. Siremadlin succinate blocks the p53-binding pocket of MDM2, inhibits MDM2-mediated ubiquitination and degradation of p53, thereby activating the p53 pathway in p53 wild-type cells. Siremadlin succinate can be used in the research of cutaneous melanoma. | |||||||||||||||||||||
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