1638288-31-9
1638288-31-9
Chemical Structure
Gemcitabine monophosphate disodium
Synonym(s): Gemcitabine 5′-phosphate disodium
- CAS No.: 1638288-31-9
- Formula:C9H10F2N3Na2O7P
- Molecular Weight:387.14
IUPAC Name: sodium ((2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl phosphate
InChIKey: JVSFEPHISQCATF-AGPLKARSSA-L
SMILES: O=P(O[Na])(O[Na])OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(N)=NC2=O)O1
Biological Activity: Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2].
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Gemcitabine monophosphate disodium | Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles. | |||||||||||||||||||||
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References
- [1]. Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21(8):1559-69. [Content Brief]
- [2]. Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24(42):6601-6611. [Content Brief]
