1639040-94-0
1639040-94-0
Chemical Structure
pan-HER-IN-1
- CAS No.: 1639040-94-0
- Formula:C19H14BrN5O
- Molecular Weight:408.25
IUPAC Name: N-(4-((3-bromo-1H-indol-5-yl)amino)quinazolin-6-yl)acrylamide
InChIKey: ATUXFPJRTSKHFB-UHFFFAOYSA-N
SMILES: C=CC(NC1=CC=C2N=CN=C(C2=C1)NC3=CC4=C(NC=C4Br)C=C3)=O
Biological Activity: pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities[1].
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pan-HER-IN-1 | pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HER inhibitor with IC50 values of 0.38, 1.6, 2.2 and 3.5 nM against EGFR, HER4, EGFRT790M/L858R and HER2, respectively. pan-HER-IN-1 induces apoptosis and shows antitumor activities. | |||||||||||||||||||||
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