1639422-97-1
1639422-97-1
Chemical Structure
JH-VIII-157-02
- CAS No.: 1639422-97-1
- Formula:C28H27N5O2
- Molecular Weight:465.55
IUPAC Name: 2-(4-(3-cyano-9-ethyl-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazol-8-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide
InChIKey: IDGNCVHQDDOPND-UHFFFAOYSA-N
SMILES: O=C(N(C)C)CN1N=CC(C2=C(CC)C=C3C(C(C)(C)C(NC4=C5C=CC(C#N)=C4)=C5C3=O)=C2)=C1
Biological Activity: JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.
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JH-VIII-157-02 | 98.98% | JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. | ||||||||||||||||||||
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