1639784-02-3
Chemical Structure
MC-100093
- CAS No.: 1639784-02-3
- Formula:C13H23N3O3
- Molecular Weight:269.34
InChIKey: WAYMKULYKCTSIQ-GWOFURMSSA-N
SMILES: O=C(N1CCN(CC1)C)[C@@H]([C@]2([H])[C@@](C(N2)=O)([H])[C@H](O)C)C
Biological Activity: MC-100093 is an orally active, blood-brain barrier-permeable GLT-1 expression upregulator. MC-100093 upregulates the expression of GLT-1 and xCT in rats, and alleviates sedative agent-induced GLT-1 downregulation, IL-6 upregulation and motor hyperactivity. MC-100093 upregulates GLT-1 expression and enhances glutamate uptake in astrocyte-neuron co-culture systems. MC-100093 reduces ethanol consumption and preference, and exerts gender-specific antidepressant-like effects. MC-100093 can be used in studies related to sedative agent overdose, mood disorders and alcohol use disorders[1][2][3][4].
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MC-100093 | 98.59% | MC-100093 is an orally active, blood-brain barrier-permeable GLT-1 expression upregulator. MC-100093 upregulates the expression of GLT-1 and xCT in rats, and alleviates sedative agent-induced GLT-1 downregulation, IL-6 upregulation and motor hyperactivity. MC-100093 upregulates GLT-1 expression and enhances glutamate uptake in astrocyte-neuron co-culture systems. MC-100093 reduces ethanol consumption and preference, and exerts gender-specific antidepressant-like effects. MC-100093 can be used in studies related to sedative agent overdose, mood disorders and alcohol use disorders. | ||||||||||||||||||||
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References
- [1]. Alotaibi A, et al. Effects of MC-100093 on Ethanol Drinking and the Expression of Astrocytic Glutamate Transporters in the Mesocorticolimbic Brain Regions of Male and Female Alcohol-Preferring Rats. Neuroscience. 2024;552:89-99. [Content Brief]
- [2]. Alasmari MS, et al. Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone. Toxics. 2024;12(8):604. Published 2024 Aug 19. [Content Brief]
- [3]. Knackstedt LA, et al. MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats. J Pharmacol Exp Ther. 2021;378(2):51-59. [Content Brief]
- [4]. León BE, et al. A novel monobactam lacking antimicrobial activity, MC-100093, reduces sex-specific ethanol preference and depressive-like behaviors in mice. Neuropharmacology. 2023 Jul 1;232:109515. [Content Brief]
