164025-33-6
Chemical Structure
PWZ-029
- CAS No.: 164025-33-6
- Formula:C14H14ClN3O2
- Molecular Weight:291.73
IUPAC Name: 8-chloro-3-(methoxymethyl)-5-methyl-4,5-dihydro-6H-benzo[f]imidazo[1,5-a][1,4]diazepin-6-one
InChIKey: FXIDXTIMKAEBGY-UHFFFAOYSA-N
SMILES: O=C1N(CC2=C(N=CN2C3=CC=C(C=C13)Cl)COC)C
Biological Activity: PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model[1][2].
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PWZ-029 | PWZ-029 is a selective inverse agonist for 5 GABAA receptors. PWZ-029 is a benzodiazepine site ligand. PWZ-029 shows a weak but significant partial agonistic effect at 1- and 3-containing receptors. PWZ-029 significantly increases retention session latency in mouse fibroblast cells. PWZ-029 can improve object recognition in normal and scopolamine-treated rat model. | |||||||||||||||||||||
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References
- [1]. Milić, M., et al., (2013). PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats. Behavioural brain research, 241, 206-213. [Content Brief]
- [2]. Savić, M. M., et al., (2008). PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. Brain research, 1208, 150-159. [Content Brief]
