1640364-04-0
1640364-04-0
Chemical Structure
DYRKi
- CAS No.: 1640364-04-0
- Formula:C20H13F3N4O2S
- Molecular Weight:430.40
IUPAC Name: 2-(2,3-dihydrobenzofuran-5-yl)-N-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide
InChIKey: IINDNGLKYISGRR-UHFFFAOYSA-N
SMILES: O=C(NC1=NC2=CC(C(F)(F)F)=CC=C2N1)C3=CSC(C4=CC=C5OCCC5=C4)=N3
Biological Activity: DYRKi is an inhibitor of DYRK1 and DYRK1B with IC50 values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers[1].
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DYRKi | DYRKi is an inhibitor of DYRK1 and DYRK1B with IC50 values of 3.7 µM and 90 nM, respectively, which is used as a potent antagonist of Hh/Gli signaling. DYRKi impairs SMO-dependent and SMO-independent oncogenic GLI activity in human medulloblastoma cells. DYRKi is promising for research of HH/GLI-associated cancers. | |||||||||||||||||||||
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