164200-23-1
164200-23-1
Chemical Structure
Antimalarial agent-72
- CAS No.: 164200-23-1
- Formula:C15H22O6
- Molecular Weight:298.33
InChIKey: JKPAMOJFZGPCQN-XEBJWQRVSA-N
SMILES: OC([C@@]1(C)O[C@]2([H])O[C@@]3(C)CC[C@]4([H])[C@@]2(OO3)[C@@]1([H])CC[C@H]4C)=O
Biological Activity: Antimalarial agent-72 is a ring-contracted Artemisinin (HY-B0094) derivative. Antimalarial agent-72 can be used to synthesize the hydrophobic tag (Hyt) degrader HDAC6 degrader-6 (HY-189299). Antimalarial agent-72 can be used for research on leukemia and malaria[1][2].
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Antimalarial agent-72 | Antimalarial agent-72 is a ring-contracted Artemisinin (HY-B0094) derivative. Antimalarial agent-72 can be used to synthesize the hydrophobic tag (Hyt) degrader HDAC6 degrader-6 (HY-189299). Antimalarial agent-72 can be used for research on leukemia and malaria. | |||||||||||||||||||||
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References
- [1]. Wang C, et al. Artemisinin-derived hydrophobic tags: structural modification and structure-activity relationship exploration of HDAC6/1 targeting degraders with potent antileukemic efficacy. Bioorganic chemistry. 2026 Oct 05;181:110275.
- [2]. Venugopalan B, et al. Antimalarial activity of novel ring-contracted artemisinin derivatives. J Med Chem. 1995 May 26;38(11):1922-7.
