1642839-27-7
1642839-27-7
Chemical Structure
GRK5-IN-2
- CAS No.: 1642839-27-7
- Formula:C20H20N4O4
- Molecular Weight:380.40
IUPAC Name: 2-(furan-2-yl)-1-methyl-N-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridin-6-amine
InChIKey: CRUXKUKVTMZKSO-UHFFFAOYSA-N
SMILES: COC1=C(OC)C(OC)=CC(NC2=CC3=C(N=C(C4=CC=CO4)N3C)C=N2)=C1
Biological Activity: GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research[1][2].
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GRK5-IN-2 | 99.89% | GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research. | ||||||||||||||||||||
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References
- [1]. Axel Ullrich (Prof. Dr.), et al. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators. EP2818472A1.
- [2]. Key CC, et al., GRK5 is required for adipocyte differentiation through ERK activation. Res Sq [Preprint]. 2024 May 17:rs.3.rs-4360297. [Content Brief]
