1644386-60-6
1644386-60-6
Chemical Structure
Iso-AS601245 TFA
- CAS No.: 1644386-60-6
- Formula:C24H18F6N6O4S
- Molecular Weight:600.49
InChIKey: LSRYQOKRGOFRBD-WTBAQZMLSA-N
SMILES: OC(C(F)(F)F)=O.N#C/C(C1=NC(NCCC2=CN=CC=C2)=NC=C1)=C3NC4=CC=CC=C4S/3.OC(C(F)(F)F)=O
Biological Activity: Iso-AS601245 TFA is an orally active JNK inhibitor, with IC50 values of 0.15 μM, 0.22 μM and 0.07 μM against JNK1, JNK2 and JNK3, respectively. Iso-AS601245 TFA reduces plasma TNF-α levels in mice and inhibits IL-2 secretion in activated T cells. Iso-AS601245 TFA alleviates adjuvant-induced rheumatoid arthritis in mice. Iso-AS601245 TFA can be used in studies related to rheumatoid arthritis[1].
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Iso-AS601245 TFA | Iso-AS601245 TFA is an orally active JNK inhibitor, with IC50 values of 0.15 μM, 0.22 μM and 0.07 μM against JNK1, JNK2 and JNK3, respectively. Iso-AS601245 TFA reduces plasma TNF-α levels in mice and inhibits IL-2 secretion in activated T cells. Iso-AS601245 TFA alleviates adjuvant-induced rheumatoid arthritis in mice. Iso-AS601245 TFA can be used in studies related to rheumatoid arthritis. | |||||||||||||||||||||
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