1644443-92-4
Chemical Structure
GW406108X
Synonym(s): GW108X
- CAS No.: 1644443-92-4
- Formula:C20H11Cl2NO4
- Molecular Weight:400.21
IUPAC Name: (Z)-3-(3,5-dichloro-4-hydroxybenzylidene)-5-(furan-2-carbonyl)indolin-2-one
InChIKey: XKTUKRBLWOHYIL-MLPAPPSSSA-N
SMILES: O=C1NC2=C(C=C(C(C3=CC=CO3)=O)C=C2)/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4
Biological Activity: GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK[1][2].
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GW406108X | 98.0% | GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK. | ||||||||||||||||||||
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References
- [1]. Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477(4):801-814. [Content Brief]
- [2]. Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29(2):148-154. [Content Brief]
