1644498-54-3
1644498-54-3
Chemical Structure
JNK-IN-25
- CAS No.: 1644498-54-3
- Formula:C28H27N7O2
- Molecular Weight:493.56
InChIKey: RADRIIWGHYFWPP-WEVVVXLNSA-N
SMILES: O=C(C1=CC(NC(/C=C/CN(C)C)=O)=CC=C1)NC(C=C2)=CC=C2NC3=NC=CC(C4=CN=CC=C4)=N3
Biological Activity: JNK-IN-25 is a potent and selective JNK1/2/3 inhibitor with IC50 values of 1.54 (JNK1), 1.99 (JNK2), and 0.75 nM (JNK3), respectively. JNK-IN-25 inhibits phosphorylation of c-Jun in cells via covalently bonding with the conserved cysteine of JNK1/2/3. JNK-IN-25 can be used for research of cancer, inflammatory and neurodegenerative diseases[1].
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JNK-IN-25 | JNK-IN-25 is a potent and selective JNK1/2/3 inhibitor with IC50 values of 1.54 (JNK1), 1.99 (JNK2), and 0.75 nM (JNK3), respectively. JNK-IN-25 inhibits phosphorylation of c-Jun in cells via covalently bonding with the conserved cysteine of JNK1/2/3. JNK-IN-25 can be used for research of cancer, inflammatory and neurodegenerative diseases. | |||||||||||||||||||||
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