1644645-32-8
1644645-32-8
Chemical Structure
Zabaglurant
Synonym(s): HTL0014242; HTL14242
- CAS No.: 1644645-32-8
- Formula:C16H8ClFN4
- Molecular Weight:310.71
IUPAC Name: 3-chloro-5-(6-(5-fluoropyridin-2-yl)pyrimidin-4-yl)benzonitrile
InChIKey: FQAXDSVNYVVQSE-UHFFFAOYSA-N
SMILES: N#CC1=CC(C2=NC=NC(C3=NC=C(F)C=C3)=C2)=CC(Cl)=C1
Biological Activity: HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively[1]. HTL14242 can be used for the research of parkinson’s disease[2].
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Zabaglurant | 98.06% | HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi and a pIC50 of 9.3 and 9.2, respectively. HTL14242 can be used for the research of parkinson’s disease. | ||||||||||||||||||||
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References
- [1]. Kirstie A Bennett, et al. Structure-based Discovery and Development of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Adv Pharmacol. . 2020;88:35-58. [Content Brief]
- [2]. John A Christopher, et al. Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J Med Chem. . 2015 Aug 27;58(16):6653-64. [Content Brief]
