1648797-46-9
1648797-46-9
Chemical Structure
Entospletinib dimesylate
Synonym(s): GS-9973 dimesylate
- CAS No.: 1648797-46-9
- Formula:C25H29N7O7S2
- Molecular Weight:603.67
IUPAC Name: 6-(1H-indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine methanesulfonate
InChIKey: WVOJPPFIOABHAB-UHFFFAOYSA-N
SMILES: O=S(O)(C)=O.O=S(O)(C)=O.C1(C=NN2)=C2C=C(C3=CN4C=CN=C4C(NC5=CC=C(N6CCOCC6)C=C5)=N3)C=C1
Biological Activity: Entospletinib dimesylate (GS-9973 dimesylate) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM[1][2].
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Entospletinib dimesylate | Entospletinib dimesylate (GS-9973 dimesylate) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM. | |||||||||||||||||||||
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References
- [1]. Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57(9):3856-73. [Content Brief]
- [2]. Burke RT, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014 Feb 28;5(4):908-15. [Content Brief]
