165133-85-7
Chemical Structure
NFAT-133
- CAS No.: 165133-85-7
- Formula:C17H24O3
- Molecular Weight:276.37
InChIKey: FTTQBBNJVTYJPS-IVZWMNDCSA-N
SMILES: CC([C@@H](C)[C@H](O)[C@H](C1=C(C=C(C=C1)C)/C=C/CO)C)=O
Biological Activity: NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056)[1][2][3][4].
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NFAT-133 | NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056). | |||||||||||||||||||||
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References
- [1]. Yang Y, et al. Absolute configuration of NFAT-133, an aromatic polyketide with immunosuppressive and antidiabetic activity from actinomycetes. J Antibiot (Tokyo). 2016 Jan;69(1):69-71. [Content Brief]
- [2]. Thakkar CS, et al. NFAT-133 increases glucose uptake in L6 myotubes by activating AMPK pathway. Eur J Pharmacol. 2015 Dec 15;769:117-26. [Content Brief]
- [3]. Zhou W, et al. Identification and Biological Activity of NFAT-133 Congeners from Streptomyces pactum. J Nat Prod. 2021 Sep 24;84(9):2411-2419. [Content Brief]
- [4]. Kulkarni-Almeida AA, et al. Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667. AMB Express. 2011 Nov 21;1(1):42. [Content Brief]
