16545-23-6
16545-23-6
Chemical Structure
Xanthomicrol
- CAS No.: 16545-23-6
- Formula:C18H16O7
- Molecular Weight:344.32
IUPAC Name: 5-hydroxy-2-(4-hydroxyphenyl)-6,7,8-trimethoxy-4H-chromen-4-one
InChIKey: SAMBWAJRKKEEOR-UHFFFAOYSA-N
SMILES: COC1=C(OC)C(OC)=C2C(C(C=C(C3=CC=C(O)C=C3)O2)=O)=C1O
Biological Activity: Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Xanthomicrol | 99.14% | Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1. | ||||||||||||||||||||
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5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone | 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone is a Flavonoids product that can be isolated from the roots of Scutellaria baicalensis Georgi. | |||||||||||||||||||||
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Gardenin D | 99.85% | Gardenin D is a natural product. Gardenin D can be isolated from the leaves of Isodon rubescens var. lushiensis. | ||||||||||||||||||||
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8-Methoxycirsilineol | 8-Methoxycirsilineol (7-Methylsudachitin) is a natural flavonoid. | |||||||||||||||||||||
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Tenaxin I | 99.53% | Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity. | ||||||||||||||||||||
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Sideritoflavone | Sideritoflavone is a flavonoid. Sideritoflavone can be isolated from Baccharis densiflora. Sideritoflavone is toxic to JIMT-1 breast cancer cells. | |||||||||||||||||||||
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Nevadensin (Standard) | ≥98% | Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities. | ||||||||||||||||||||
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Demethoxysudachitin | Demethoxysudachitin is a natural flavonoid. | |||||||||||||||||||||
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5-O-Demethylnobiletin | 99.91% | 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM. | ||||||||||||||||||||
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Isothymusin | Isothymusin is a potent anti-oxidant agent. Isothymusin shows radical scavenging activities. Isothymusin shows anti-proliferative activities in cancer cell lines. Isothymusin inhibited the enzymes associated with the promotion stage of cancer, including cycloxygenase- 2 and lipoxygenase-5. | |||||||||||||||||||||
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Gardenin B (Standard) | ≥98% | Gardenin B (Standard) is the analytical standard of Gardenin B (HY-N6037). This product is intended for research and analytical applications. Gardenin B is a flavonoid isolated from Gardenia jasminoides. Gardenin B is a methoxyflavone compound and an inhibitor of USP7, ODC (IC50: 6.24 μg/mL), and Cathepsin D (IC50: 5.61 μg/mL). Gardenin B exhibits antioxidant and antitumor activities. Gardenin B shows IC50 values of 8.87 and 10.59 μg/mL for DPPH and NO scavenging, respectively, and also possesses ferric ion reducing ability. Additionally, Gardenin B can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. Gardenin B can be used in cancer research. | ||||||||||||||||||||
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References
- [1]. F. A. TOMAS-BARBERAN, et al. Epicuticular Flavonoids from Beffardia trixago and their Antifungal Fully Methylated Derivatives. Int. J. Crude Drug Res., 28 (l990), No. I, pp. 57-60.
- [2]. Fereshteh Jahaniani, et al. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005 Jul;66(13):1581-92. [Content Brief]
- [3]. Shanshan Guo, et al. Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Function. 30-Apr-2018.
- [4]. Fatma Pinar Turkmenoglu, et al. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol. Molecules. 2015 Apr 23;20(5):7454-73. [Content Brief]
- [5]. Shanshan Guo, et al. Identification of xanthomicrol as a major colonic metabolite of 5-demethyltangeretin in mice and their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Food & Function. 30-Apr-2018.
