1655504-04-3
Chemical Structure
Orelabrutinib
Synonym(s): ICP-022
- CAS No.: 1655504-04-3
- Formula:C26H25N3O3
- Molecular Weight:427.50
IUPAC Name: 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide
InChIKey: MZPVEMOYADUARK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2CCN(C(C=C)=O)CC2)N=C1C3=CC=C(OC4=CC=CC=C4)C=C3)N
Biological Activity: Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK[1][2].
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Orelabrutinib | 99.97% | Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK. | ||||||||||||||||||||
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