1660153-08-1
1660153-08-1
Chemical Structure
NDB
- CAS No.: 1660153-08-1
- Formula:C26H28Cl2N2O2
- Molecular Weight:471.42
IUPAC Name: N-benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino)benzamide
InChIKey: IDACWMHIKWNAEO-UHFFFAOYSA-N
SMILES: O=C(N(C1=CC=C(O)C(C(C)(C)C)=C1)CC2=CC=CC=C2)C3=C(Cl)C=C(N(C)C)C=C3Cl
Biological Activity: NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NDB | 98.36% | NDB is a selective human FXRα (hFXRα) antagonist that is effective in modulating transcription of FXRα downstream genes. NDB can be used in anti-diabetes research. | ||||||||||||||||||||
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References
- [1]. Xing Xu, et al. Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. J Biol Chem. 2015 Aug 7;290(32):19888-99. [Content Brief]
