166527-00-0
166527-00-0
Chemical Structure
7-Desmethyl-3-hydroxyagomelatine
Synonym(s): 3-Hydroxy-7-desmethyl agomelatine
- CAS No.: 166527-00-0
- Formula:C14H15NO3
- Molecular Weight:245.27
IUPAC Name: N-(2-(3,7-dihydroxynaphthalen-1-yl)ethyl)acetamide
InChIKey: FMUHSDLSKQLNNB-UHFFFAOYSA-N
SMILES: CC(NCCC1=C2C=C(O)C=CC2=CC(O)=C1)=O
Biological Activity: 7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine[1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[1][2].
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7-Desmethyl-3-hydroxyagomelatine | 7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist. | |||||||||||||||||||||
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References
- [1]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6. [Content Brief]
- [2]. Kennedy SH, et al. Agomelatine and its therapeutic potential in the depressed patient. Neuropsychiatr Dis Treat. 2007 Aug;3(4):423-8. [Content Brief]
