16659-88-4
16659-88-4
Chemical Structure
Tetrahydropapaveroline hydrobromide
Synonym(s): Norlaudanosoline hydrobromide
- CAS No.: 16659-88-4
- Formula:C16H18BrNO4
- Molecular Weight:368.22
IUPAC Name: 1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrobromide
InChIKey: WAADYLVPNMRUKN-UHFFFAOYSA-N
SMILES: OC1=CC=C(CC2NCCC3=CC(O)=C(C=C32)O)C=C1O.Br
Biological Activity: Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [3H]DA uptake with a Ki of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction[1][2].
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Tetrahydropapaveroline hydrobromide | 99.82% | Tetrahydropapaveroline (Norlaudanosoline) hydrobromide, an isoquinoline alkaloid, is a condensation product of dopamine and dopaldehyde. Tetrahydropapaveroline hydrobromide inhibits [3H]DA uptake with a Ki of 41 μM. Tetrahydropapaveroline hydrobromide can be used for the study of Parkinson's disease and/or alcohol addiction. | ||||||||||||||||||||
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References
- [1]. Zhu W, Mantione KJ, Shen L, Lee B, Stefano GB. Norlaudanosoline and nicotine increase endogenous ganglionic morphine levels: nicotine addiction. Cell Mol Neurobiol. 2006;26(4-6):1037-1045. [Content Brief]
- [2]. Okada T, et al. Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through dopamine transporter expressed in HEK293 cells. Neurosci Res. 1998 Jan;30(1):87-90. [Content Brief]
