1667730-59-7
1667730-59-7
Chemical Structure
(Z)-NMac1
- CAS No.: 1667730-59-7
- Formula:C24H28O4
- Molecular Weight:380.48
SMILES: COC(C=C1/C=C\C2C(C3=CC(OC)=C(C=C3)OC)C=CCC2)=C(C=C1)OC
Biological Activity: (Z)-NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z)-NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z)-NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z)-NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment[1].
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(Z)-NMac1 | (Z)-NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z)-NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z)-NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z)-NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment. | |||||||||||||||||||||
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