1668565-74-9
1668565-74-9
Chemical Structure
PCC0208009
- CAS No.: 1668565-74-9
- Formula:C29H35N7O
- Molecular Weight:497.63
IUPAC Name: 1-(4-(diisobutylamino)-2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-3-(p-tolyl)urea
InChIKey: CJNMMPAEIYFQIJ-UHFFFAOYSA-N
SMILES: CC(C)CN(CC(C)C)C1=CC=C(C2=CC=CC=C2C3=NN=NN3)C=C1NC(NC4=CC=C(C)C=C4)=O
Biological Activity: PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala [1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PCC0208009 | 98.06% | PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala . | ||||||||||||||||||||
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References
- [1]. Yu Wang, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020 Jul;177:113926. [Content Brief]
- [2]. David K Williams, et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736. [Content Brief]
