166981-11-9
Chemical Structure
CT 2576
- CAS No.: 166981-11-9
- Formula:C26H47N5O3
- Molecular Weight:477.69
IUPAC Name: 1-(10-hydroxy-11-(octylamino)undecyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChIKey: BDKVACCVHNPPIG-UHFFFAOYSA-N
SMILES: O=C1C2=C(N=CN2C)N(C(=O)N1CCCCCCCCCC(O)CNCCCCCCCC)C
Biological Activity: CT 2576 is a phospholipid signaling inhibitor as well as a Jak3/STAT5 inhibitor. CT 2576 suppresses gene expression and replication of human immunodeficiency virus (HIV) at the post-transcriptional level by interfering with phospholipid metabolism in host cells, particularly by inhibiting the production of phosphatidic acid PA. CT-2576 completely inhibits the growth and proliferation of malignant T-cell lymphoma cells by suppressing phospholipid signaling and blocking the Jak/STAT signaling pathway associated with IL-2R. CT 2576 can be used in research related to human immunodeficiency virus (HIV) infection and cutaneous T-cell lymphoma (CTCL)[1][2].
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CT 2576 | CT 2576 is a phospholipid signaling inhibitor as well as a Jak3/STAT5 inhibitor. CT 2576 suppresses gene expression and replication of human immunodeficiency virus (HIV) at the post-transcriptional level by interfering with phospholipid metabolism in host cells, particularly by inhibiting the production of phosphatidic acid PA. CT-2576 completely inhibits the growth and proliferation of malignant T-cell lymphoma cells by suppressing phospholipid signaling and blocking the Jak/STAT signaling pathway associated with IL-2R. CT 2576 can be used in research related to human immunodeficiency virus (HIV) infection and cutaneous T-cell lymphoma (CTCL). | |||||||||||||||||||||
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References
- [1]. Leung DW, et al. CT-2576, an inhibitor of phospholipid signaling, suppresses constitutive and induced expression of human immunodeficiency virus. Proceedings of the National Academy of Sciences of the United States of America. 1995 May 23;92(11):4813-7.
- [2]. Wasik MA, et al. Suppression of proliferation and phosphorylation of Jak3 and STAT5 in malignant T-cell lymphoma cells by derivatives of octylamino-undecyl-dimethylxanthine. Leukemia & lymphoma. 1998 Feb;28(5-6):551-60.
