167027-99-8
Chemical Structure
L-162537
- CAS No.: 167027-99-8
- Formula:C38H32N8O2
- Molecular Weight:632.71
IUPAC Name: N-(3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-oxo-2-propyl-3,4-dihydroquinazolin-6-yl)-N-(pyridin-3-ylmethyl)benzamide
InChIKey: LTOXCHHKSRUNNW-UHFFFAOYSA-N
SMILES: CCCC1=NC2=C(C(N1CC3=CC=C(C4=C(C5=NNN=N5)C=CC=C4)C=C3)=O)C=C(N(CC6=CN=CC=C6)C(C7=CC=CC=C7)=O)C=C2
Biological Activity: L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension[1].
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L-162537 | L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension. | |||||||||||||||||||||
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