167298-74-0
Chemical Structure
SCH 51866
- CAS No.: 167298-74-0
- Formula:C19H18F3N5O
- Molecular Weight:389.37
IUPAC Name: (6aS,9aR)-5-methyl-2-(4-(trifluoromethyl)benzyl)-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(1H)-one
InChIKey: JOSMPBVYYKRYLG-QWHCGFSZSA-N
SMILES: CN1C2=N[C@](CCC3)([H])[C@]3([H])N2C4=C(C1=O)N=C(N4)CC5=CC=C(C=C5)C(F)(F)F
Biological Activity: SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension[1].
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SCH 51866 | SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC50=70 nM) and PDE5 (IC50=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC50=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension. | |||||||||||||||||||||
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