168016-90-8
Chemical Structure
BIM-23197
- CAS No.: 168016-90-8
- Formula:C57H81N13O13S3
- Molecular Weight:1252.53
IUPAC Name: (4R,7S,10S,13R,16S,19R)-13-((1H-indol-3-yl)methyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-10-(4-aminobutyl)-7-ethyl-16-(4-hydroxybenzyl)-19-((R)-2-((2-(4-(2-hydroxyethyl)piperazin-1-yl)ethyl)sulfonamido)-3-phenylpropanamido)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
InChIKey: ABXKTKZCYNKQOZ-RPPDHWCPSA-N
SMILES: O=C([C@@H](NC([C@H](CSSC[C@H](NC([C@@H](NC([C@@H](NC1=O)CCCCN)=O)CC)=O)C(N[C@H](C(N)=O)[C@H](O)C)=O)NC([C@H](NS(CCN2CCN(CC2)CCO)(=O)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=C(C=C4)O)N[C@@H]1CC5=CNC6=CC=CC=C56
Biological Activity: BIM-23197 is a selective SST2 (IC50 = 0.19 nM) agonist. BIM-23197 can effectively stimulate intracellular calcium mobilization in cells expressing SST2. BIM-23197 can be used for research on endocrine related conditions[1].
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BIM-23197 | BIM-23197 is a selective SST2 (IC50 = 0.19 nM) agonist. BIM-23197 can effectively stimulate intracellular calcium mobilization in cells expressing SST2. BIM-23197 can be used for research on endocrine related conditions. | |||||||||||||||||||||
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References
- [1]. Tulipano G, et al. Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment. Endocrinology. 2002 Apr;143(4):1218-24. [Content Brief]
