168158-16-5
168158-16-5
Chemical Structure
KB-R7785
- CAS No.: 168158-16-5
- Formula:C18H27N3O4
- Molecular Weight:349.42
IUPAC Name: (2S,3R)-N1-hydroxy-3-isobutyl-2-methyl-N4-((S)-2-(methylamino)-2-oxo-1-phenylethyl)succinamide
InChIKey: OFCWIPGKPUJTDP-CFVMTHIKSA-N
SMILES: ONC([C@@H](C)[C@@H](CC(C)C)C(N[C@@H](C1=CC=CC=C1)C(NC)=O)=O)=O
Biological Activity: KB-R7785 is a matrix metalloproteinase (MMP) inhibitor, which improves insulin sensitivity by inhibiting TNF-α production. KB-R7785 can be used for diabetes research. KB-R7785 has a protective efficacy against focal cerebral ischemia[1][2].
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KB-R7785 | 99.90% | KB-R7785 is a matrix metalloproteinase (MMP) inhibitor, which improves insulin sensitivity by inhibiting TNF-α production. KB-R7785 can be used for diabetes research. KB-R7785 has a protective efficacy against focal cerebral ischemia. | ||||||||||||||||||||
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References
- [1]. Morimoto Y, et al. KB-R7785, a novel matrix metalloproteinase inhibitor, exerts its antidiabetic effect by inhibiting tumor necrosis factor-alpha production. Life Sci. 1997;61(8):795-803. [Content Brief]
- [2]. Jiang X, et al. Matrix metalloproteinase inhibitor KB-R7785 attenuates brain damage resulting from permanent focal cerebral ischemia in mice. Neurosci Lett. 2001 Jun 1;305(1):41-4. [Content Brief]
