16836-31-0
16836-31-0
Chemical Structure
Kauran-16,17-diol
Synonym(s): ent-Kauran-16β,17-diol
- CAS No.: 16836-31-0
- Formula:C20H34O2
- Molecular Weight:306.48
IUPAC Name: (4aR,6aS,8R,9R,11aR,11bR)-8-(hydroxymethyl)-4,4,11b-trimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalen-8-ol
InChIKey: LCYWCTWYVKIBSA-URTLRTLISA-N
SMILES: C[C@]1(CCC2)[C@@]3([H])[C@](C[C@H]4CC3)(CC[C@]1([H])C2(C)C)C[C@]4(O)CO
Biological Activity: Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Kauran-16,17-diol | 99.80% | Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages. | ||||||||||||||||||||
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References
- [1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. [Content Brief]
- [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8. [Content Brief]
