168620-46-0
168620-46-0
Chemical Structure
FR168888
- CAS No.: 168620-46-0
- Formula:C14H18N4O5S
- Molecular Weight:354.38
IUPAC Name: N-carbamimidoyl-3-(hydroxymethyl)-5-(1H-pyrrol-1-yl)benzamide methanesulfonate
InChIKey: MONFTTJJXAHULM-UHFFFAOYSA-N
SMILES: O=C(NC(N)=N)C1=CC(N2C=CC=C2)=CC(CO)=C1.CS(=O)(O)=O
Biological Activity: FR-168888 is a Na+/H+ exchanger (NHE) inhibitor (Ki=6.4 nM) with weak inhibitory activity against Na+/Ca2+ exchanger and no cardioprotective effects. FR-168888 is widely applicable to studies related to reperfusion-induced ventricular arrhythmias[1][2].
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FR168888 | FR-168888 is a Na+/H+ exchanger (NHE) inhibitor (Ki=6.4 nM) with weak inhibitory activity against Na+/Ca2+ exchanger and no cardioprotective effects. FR-168888 is widely applicable to studies related to reperfusion-induced ventricular arrhythmias. | |||||||||||||||||||||
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References
- [1]. Zhu B M, et al. Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat[J]. Japanese journal of pharmacology, 2002, 88(1): 93-99.
- [2]. F Ohara, et al. Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds. Jpn J Pharmacol. 1999 Aug;80(4):295-302. [Content Brief]
