169209-63-6
Chemical Structure
(2R,4R)-APDC
Synonym(s): (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid
- CAS No.: 169209-63-6
- Formula:C6H10N2O4
- Molecular Weight:174.15
IUPAC Name: (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid
InChIKey: XZFMJVJDSYRWDQ-AWFVSMACSA-N
SMILES: O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
Biological Activity: (2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases[1][2].
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(2R,4R)-APDC | (2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases. | |||||||||||||||||||||
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References
- [1]. Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54. [Content Brief]
- [2]. Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62. [Content Brief]
