16961-77-6
16961-77-6
Chemical Structure
CPA-7
- CAS No.: 16961-77-6
- Formula:Cl3H6N3O2Pt
- Molecular Weight:381.51
InChIKey: KAIQQZAGEUGWAJ-UHFFFAOYSA-K
SMILES: O=[N-]([Pt+4]([Cl-])([Cl-])([NH3])([NH3])[Cl-])=O
Biological Activity: CPA7 is a novel Stat3 inhibitor. CPA7 downregulates survivin, Bcl-XL, and Mcl-1. CPA7 induces Apoptosis. CPA7 enhances the radiosensitivity of prostate cancer. CPA7 has anti-cancer effects against prostate cancer[1][2].
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CPA-7 | CPA7 is a novel Stat3 inhibitor. CPA7 downregulates survivin, Bcl-XL, and Mcl-1. CPA7 induces Apoptosis. CPA7 enhances the radiosensitivity of prostate cancer. CPA7 has anti-cancer effects against prostate cancer. | |||||||||||||||||||||
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References
- [1]. Sekharam M, et al. CPA7, a novel Stat3 inhibitor radiosensitizes prostate cancer cells. International Journal of Radiation Oncology, Biology, Physics, 2005, 63: S483.
- [2]. Liang M, et al. CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3. BMC Cancer. 2016 Jul 19;16:504. [Content Brief]
