170116-63-9
170116-63-9
Chemical Structure
Z-Pro-Pro-aldehyde-dimethyl acetal
- CAS No.: 170116-63-9
- Formula:C20H28N2O5
- Molecular Weight:376.45
InChIKey: FWRIGQASSHUNQU-IRXDYDNUSA-N
SMILES: O=C([C@H]1N(CCC1)C(OCC2=CC=CC=C2)=O)N3[C@@H](CCC3)C(OC)OC
Biological Activity: Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease[1][2].
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Z-Pro-Pro-aldehyde-dimethyl acetal | Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. [Content Brief]
- [2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. [Content Brief]
