170148-29-5
Chemical Structure
JTV-506
- CAS No.: 170148-29-5
- Formula:C19H22N4O5
- Molecular Weight:386.40
IUPAC Name: (3S,4R)-3-hydroxy-2,2-bis(methoxymethyl)-4-((1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)amino)chromane-6-carbonitrile
InChIKey: FMCCXEOPBHXPAO-MSOLQXFVSA-N
SMILES: N#CC1=CC=C2C([C@@H](NC(C=C3)=NN(C)C3=O)[C@H](O)C(COC)(COC)O2)=C1
Biological Activity: JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204)-induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].
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JTV-506 | JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204)-induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research. | |||||||||||||||||||||
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References
- [1]. Ando T, et al. Effects of JTV-506, a new K+ channel activator, on airway smooth muscle contraction and systemic blood pressure. Clin Exp Allergy. 1997 Jun;27(6):705-13. [Content Brief]
- [2]. Tsutsumi Y, et al. JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. J Anesth. 2004;18(3):210-5. [Content Brief]
