17028-03-4
Chemical Structure
3-Methyl-L-tyrosine
- CAS No.: 17028-03-4
- Formula:C10H13NO3
- Molecular Weight:195.22
IUPAC Name: (S)-2-amino-3-(4-hydroxy-3-methylphenyl)propanoic acid
InChIKey: MQHLULPKDLJASZ-QMMMGPOBSA-N
SMILES: CC1=CC(=CC=C1O)C[C@@H](C(=O)O)N
Biological Activity: 3-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk[1].
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3-Methyl-L-tyrosine | 3-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk. | |||||||||||||||||||||
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