17035-90-4
17035-90-4
Chemical Structure
L-NMMA
Synonym(s): Tilarginine; Methylarginine
- CAS No.: 17035-90-4
- Formula:C7H16N4O2
- Molecular Weight:188.23
IUPAC Name: Nw-methyl-L-arginine
InChIKey: NTNWOCRCBQPEKQ-YFKPBYRVSA-N
SMILES: OC([C@@H](N)CCCNC(NC)=N)=O
Biological Activity: L-NMMA (Tilarginine) is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA is applicable to research related to nociception, bone cancer pain, and myopia[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-NMMA | 99.43% | L-NMMA (Tilarginine) is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA is applicable to research related to nociception, bone cancer pain, and myopia. | ||||||||||||||||||||
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References
- [1]. Yang Y, et al. Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA. Mol Med Rep. 2016;13(2):1220-1226. [Content Brief]
- [2]. Li T, et al. Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic guinea pigs through the nitric oxide signaling pathway. Eur J Pharmacol. 2023;960:176111. [Content Brief]
- [3]. Babbedge RC, et al. Anti-nociceptive activity of nitric oxide synthase inhibitors in the mouse: dissociation between the effect of L-NAME and L-NMMA. J Pharm Pharmacol. 1993;45(1):77-79. [Content Brief]
