170569-99-0
Chemical Structure
4-Desmethyl-2-methyl celecoxib
- CAS No.: 170569-99-0
- Formula:C17H14F3N3O2S
- Molecular Weight:381.37
IUPAC Name: 4-(5-(o-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
InChIKey: QGNNQDAQBISHQG-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC=CC=C3C)C=C1)(N)=O
Biological Activity: 4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis[1].
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4-Desmethyl-2-methyl celecoxib | 4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis. | |||||||||||||||||||||
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