170684-14-7
Chemical Structure
UK-1745
- CAS No.: 170684-14-7
- Formula:C16H23ClN2O2
- Molecular Weight:310.82
IUPAC Name: (2R,3S)-2-(aminomethyl)-2,3,5,8,8-pentamethyl-2,3,6,8-tetrahydro-7H-furo[2,3-e]indol-7-one hydrochloride
InChIKey: XVUOIQVVCCRMAY-SCKAJQSLSA-N
SMILES: CC1(C2=C(NC1=O)C(C)=CC3=C2O[C@](CN)(C)[C@H]3C)C.Cl
Biological Activity: UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure[1][2].
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UK-1745 | UK-1745 is a cardiotonic agent with vasodilating and antiarrhythmic properties. It increases intracellular levels of cyclic adenosine monophosphate (cAMP) in cardiomyocytes by inhibiting phosphodiesterase III, thereby enhancing myocardial contractility. Additionally, UK-1745 exhibits β-adrenergic receptor blocking activity, which helps reduce the oxygen consumption of the heart and prevent calcium overload. These characteristics make UK-1745 a promising candidate for research in congestive heart failure. | |||||||||||||||||||||
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References
- [1]. Sawada, et al. "Pharmacological Characterization of Effects of UK-1745, a Novel Cardiotonic Agent withβ-Adrenoceptor-blocking Action, in Aequorin-loaded Canine Right Ventricular Muscle." Journal of molecular and cellular cardiology 31.5 (1999): 1047-1062. [Content Brief]
- [2]. Uchida, et al. "Cardiovascular effects of (2RS, 3SR)-2-aminomethyl-2, 3, 7, 8-tetrahydro-2, 3, 5, 8, 8-pentamethyl-6H-furo-[2, 3-e] indol-7-one hydrochloride (UK-1745), a novel cardiotonic agent with vasodilatory and antiarrhythmic properties." Arzneimittel-forschung 48.3 (1998): 219-231. [Content Brief]
