170950-29-5
Chemical Structure
TrxR1-IN-B19
Synonym(s): GO-Y015
- CAS No.: 170950-29-5
- Formula:C21H22O5
- Molecular Weight:354.40
IUPAC Name: (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one
InChIKey: LSNRKPCFLXRJGN-PHEQNACWSA-N
SMILES: COC(C(OC)=CC=C1)=C1/C=C/C(/C=C/C2=C(C(OC)=CC=C2)OC)=O
Biological Activity: TrxR1-IN-B19 (GO-Y015) is a Curcumin (HY-N0005) derivative and TrxR1 inhibitor. TrxR1-IN-B19 inhibits de novo selenoprotein synthesis, suppresses SeP and GPx expression, and impairs selenium incorporation into Sec-tRNA[Sec]. TrxR1-IN-B19 induces Nrf2 accumulation through Keap1 cysteine modification, HO-1 expression, GSH synthesis, ROS accumulation, ER stress, mitochondrial dysfunction, Apoptosis, and G2/M phase arrest. TrxR1-IN-B19 improves glucose tolerance and insulin sensitivity, lowers blood glucose, inhibits tumor growth, and reduces arsenic accumulation. TrxR1-IN-B19 can be used for research on type 2 diabetes, arsenite-induced toxicity, and gastric cancer[1][2][3][4].
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TrxR1-IN-B19 | TrxR1-IN-B19 (GO-Y015) is a Curcumin (HY-N0005) derivative and TrxR1 inhibitor. TrxR1-IN-B19 inhibits de novo selenoprotein synthesis, suppresses SeP and GPx expression, and impairs selenium incorporation into Sec-tRNA[Sec]. TrxR1-IN-B19 induces Nrf2 accumulation through Keap1 cysteine modification, HO-1 expression, GSH synthesis, ROS accumulation, ER stress, mitochondrial dysfunction, Apoptosis, and G2/M phase arrest. TrxR1-IN-B19 improves glucose tolerance and insulin sensitivity, lowers blood glucose, inhibits tumor growth, and reduces arsenic accumulation. TrxR1-IN-B19 can be used for research on type 2 diabetes, arsenite-induced toxicity, and gastric cancer. | |||||||||||||||||||||
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References
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[1]. Yinuo W, et al. Downregulation of selenoprotein P by curcumin derivatives through covalent binding to selenium metabolism factors and its potential anti-diabetic effect[J]. 2026.
- [2]. Yinuo W, et al. Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network. Free radical biology & medicine. 2026 Sep;253:487-499.
- [3]. Islam MT, et al. Nrf2 activation by the monocarbonyl curcumin derivative GO-Y015 confers cellular protection against arsenite toxicity by reducing intracellular arsenic levels. Scientific reports. 2026 Apr 18;16(1):18048.
- [4]. Chen W, et al. Selective killing of gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. Oncotarget. 2016 Mar 29;7(13):16593-609. [Content Brief]
