1713317-28-2
1713317-28-2
Chemical Structure
GW273297X
Synonym(s): G297X
- CAS No.: 1713317-28-2
- Formula:C29H48O3
- Molecular Weight:444.69
InChIKey: PCYZBDFBDWTQEA-BXEBNXJWSA-N
SMILES: C[C@@]12[C@]3([H])[C@]([C@@H](C[C@]1([H])CC(OC)(CC2)OC)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCCC#C)C
Biological Activity: GW273297X is a selective CYP27A1 inhibitor. GW273297X blocks 27-hydroxycholesterol biosynthesis and sterol product formation in human macrophages. GW273297X reduces cancer cells colonization by inhibiting pro-metastatic effects of 27-hydroxycholesterol. GW273297X can be used for the researches of cancer and metabolic disease, such as breast cancer[1][2].
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GW273297X | GW273297X is a selective CYP27A1 inhibitor. GW273297X blocks 27-hydroxycholesterol biosynthesis and sterol product formation in human macrophages. GW273297X reduces cancer cells colonization by inhibiting pro-metastatic effects of 27-hydroxycholesterol. GW273297X can be used for the researches of cancer and metabolic disease, such as breast cancer. | |||||||||||||||||||||
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References
- [1]. Baek AE, et al. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nat Commun. 2017;8(1):864. Published 2017 Oct 11. [Content Brief]
- [2]. Quinn CM, et al. Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands. Biochem J. 2005;385(Pt 3):823-830. [Content Brief]
