171773-95-8
171773-95-8
Chemical Structure
JRN73958
Synonym(s): Reduced scytonemin
- CAS No.: 171773-95-8
- Formula:C36H24N2O4
- Molecular Weight:548.59
InChIKey: LAZAHPDIYGMLEJ-MFYXSQMNSA-N
SMILES: O=C1/C(C2NC3=C(C2=C1C(C/4=O)=C5C6=C(C=CC=C6)NC5C4=C\C7=CC=C(C=C7)O)C=CC=C3)=C\C8=CC=C(C=C8)O
Biological Activity: JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia[1][2].
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JRN73958 | JRN73958 (Reduced scytonemin) is a PI3K/Akt, MAPK, and NF-κB inhibitor found in Nostoc commune. JRN73958 inhibits nitric oxide production, induce reactive oxygen species (ROS) generation, and lead to autophagy. JRN73958 decreases LPS (HY-D1056)/IFNγ-induced PI3K/Akt, MAPK, and NF-κB activity. JRN73958 can be used for the research of leukemia. | |||||||||||||||||||||
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References
- [1]. Itoh T, et al. Reduced scytonemin isolated from Nostoc commune suppresses LPS/IFNγ-induced NO production in murine macrophage RAW264 cells by inducing hemeoxygenase-1 expression via the Nrf2/ARE pathway. Food Chem Toxicol. 2014;69:330-338. [Content Brief]
- [2]. Itoh T, et al. Reduced scytonemin isolated from Nostoc commune induces autophagic cell death in human T-lymphoid cell line Jurkat cells. Food Chem Toxicol. 2013;60:76-82. [Content Brief]
