172081-08-2
Chemical Structure
TAC 363
- CAS No.: 172081-08-2
- Formula:C38H48N8O6
- Molecular Weight:712.84
IUPAC Name: (S)-N1-((S)-1-(2-benzyl-2-((2-(benzyloxy)ethyl)carbamoyl)hydrazinyl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-2-(3-(tert-butyl)ureido)pentanediamide
InChIKey: GBIJRCYDQXCMOU-ACHIHNKUSA-N
SMILES: O=C(NCCOCC1=CC=CC=C1)N(CC2=CC=CC=C2)NC([C@@H](NC([C@H](CCC(N)=O)NC(NC(C)(C)C)=O)=O)CC3=CNC4=CC=CC=C34)=O
Biological Activity: TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma[1].
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TAC 363 | TAC 363 is a selective tachykinin NK-2 receptor antagonist. TAC 363 shows a rightward shift in the contractile response curve induced by Neurokinin A (HY-P0197) with a pA2 of 9.82. TAC 363 has a weak antagonistic effect on NK-1 receptors. TAC 363 can inhibit Neurokinin A-induced bronchoconstriction in guinea pigs with an ED50 of 0.3 mg/kg. TAC 363 can be used for the research of bronchial asthma. | |||||||||||||||||||||
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