172649-40-0
172649-40-0
Chemical Structure
ZD0947
- CAS No.: 172649-40-0
- Formula:C17H13F3N2O
- Molecular Weight:318.29
IUPAC Name: (S)-3-(5-oxo-2-(trifluoromethyl)-1,4,5,6,7,8-hexahydroquinolin-4-yl)benzonitrile
InChIKey: RUVMMEREJMHLOS-LBPRGKRZSA-N
SMILES: N#CC1=CC=CC([C@@H]2C=C(NC3=C2C(CCC3)=O)C(F)(F)F)=C1
Biological Activity: ZD0947 is an ATP-sensitive potassium channel activator with relatively effective activation of smooth muscle KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2). ZD0947 partially antagonizes pancreatic KATP channels (SUR1/Kir6.2) and cardiac KATP channels (SUR2A/Kir6.2). ZD0947 is potentially used to inhibit overactive bladder (OAB)[1].
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ZD0947 | ZD0947 is an ATP-sensitive potassium channel activator with relatively effective activation of smooth muscle KATP channels (SUR2B/Kir6.1 and SUR2B/Kir6.2). ZD0947 partially antagonizes pancreatic KATP channels (SUR1/Kir6.2) and cardiac KATP channels (SUR2A/Kir6.2). ZD0947 is potentially used to inhibit overactive bladder (OAB). | |||||||||||||||||||||
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