17274-65-6
17274-65-6
Chemical Structure
5-Bromo-N,N-dimethyltryptamine
Synonym(s): 5-Bromo-N,N-DMT
- CAS No.: 17274-65-6
- Formula:C12H15BrN2
- Molecular Weight:267.16
IUPAC Name: 2-(5-bromo-1H-indol-3-yl)-N,N-dimethylethan-1-amine
InChIKey: ATEYZYQLBQUZJE-UHFFFAOYSA-N
SMILES: BrC1=CC2=C(NC=C2CCN(C)C)C=C1
Biological Activity: 5-Bromo-N,N-dimethyltryptamine (5-Bromo-N,N-DMT) is a 5-HT receptor ligand with Ki values of 2.6 nM and 8.3 nM for 5-HT1D and 5-HT7, respectively. 5-Bromo-N,N-dimethyltryptamine induces sedative/hypolocomotor effects. 5-Bromo-N,N-dimethyltryptamine can be used for research on depression[1][2][3][4].
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5-Bromo-N,N-dimethyltryptamine | 5-Bromo-N,N-dimethyltryptamine (5-Bromo-N,N-DMT) is a 5-HT receptor ligand with Ki values of 2.6 nM and 8.3 nM for 5-HT1D and 5-HT7, respectively. 5-Bromo-N,N-dimethyltryptamine induces sedative/hypolocomotor effects. 5-Bromo-N,N-dimethyltryptamine can be used for research on depression. | |||||||||||||||||||||
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References
- [1]. Ibrahim MA, et al. Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space. Mar Drugs. 2017 Aug 9;15(8):248. [Content Brief]
- [2]. Kochanowska AJ, et al. Secondary metabolites from three Florida sponges with antidepressant activity. Journal of natural products. 2008 Feb;71(2):186-9.
- [3]. Munir S, et al. The Therapeutic Prospects of Naturally Occurring and Synthetic Indole Alkaloids for Depression and Anxiety Disorders. Evidence-based complementary and alternative medicine : eCAM. 2020;2020:8836983.
- [4]. Kochanowska-Karamyan AJ, et al. Marine indole alkaloids: potential new drug leads for the control of depression and anxiety. Chem Rev. 2010 Aug 11;110(8):4489-97.
