17291-05-3
Chemical Structure
(-)-Epigallocatechin-4'-O-methylether
Synonym(s): (-)-EGC-4'-O-ME
- CAS No.: 17291-05-3
- Formula:C16H16O7
- Molecular Weight:320.30
IUPAC Name: (2R,3R)-2-(3,5-dihydroxy-4-methoxyphenyl)chromane-3,5,7-triol
InChIKey: ITDYPNOEEHONAH-UKRRQHHQSA-N
SMILES: O[C@H]1[C@H](OC=2C(C1)=C(O)C=C(O)C2)C3=CC(O)=C(OC)C(O)=C3
Biological Activity: (-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury[1][2][3][4].
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(-)-Epigallocatechin-4'-O-methylether | (-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury. | |||||||||||||||||||||
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References
- [1]. Takahashi T, et al. Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition. PLoS One. 2018;13(10):e0204856. Published 2018 Oct 11. [Content Brief]
- [2]. Cameron AR, et al. Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a. Aging Cell. 2008 Jan;7(1):69-77. [Content Brief]
- [3]. Gonzalez JG, et al. Chuchuhuasha - a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis. J Ethnopharmacol. 1982;5(1):73-77. [Content Brief]
- [4]. Yoshikawa M, et al. Hepatoprotective and antioxidative properties of Salacia reticulata: preventive effects of phenolic constituents on CCl4-induced liver injury in mice. Biol Pharm Bull. 2002;25(1):72-76. [Content Brief]
