17575-21-2
Chemical Structure
Lanatoside B
- CAS No.: 17575-21-2
- Formula:C49H76O20
- Molecular Weight:985.12
IUPAC Name: (2R,3R,4S,6S)-6-(((2R,3S,4S,6S)-6-(((2R,3S,4S,6R)-6-(((3S,5R,8R,9S,10S,13R,14S,16S,17R)-14,16-dihydroxy-10,13-dimethyl-17-(5-oxo-2,5-dihydrofuran-3-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-4-hydroxy-2-methyltetrahydro-2H-pyran-3-yl)oxy)-2-methyl-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-4-yl acetate
InChIKey: XVAPNQFQPDAROQ-CAPSWCROSA-N
SMILES: O[C@@]12[C@@]([C@@H](C(CO3)=CC3=O)[C@@H](O)C1)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@H](O[C@@]6([H])C[C@@H]([C@H](O[C@@]7([H])C[C@@H]([C@H](O[C@@]8([H])C[C@@H]([C@H](O[C@]9([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]9O)CO)[C@@H](C)O8)OC(C)=O)[C@@H](C)O7)O)[C@@H](C)O6)O)C5)C)C
Biological Activity: Lanatoside B is an anticancer agent. Lanatoside B can be isolated from the leaves of Digitalis lanata. Lanatoside B exhibits anticancer activity against cholangiocarcinoma[1][2].
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Lanatoside B | Lanatoside B is an anticancer agent. Lanatoside B can be isolated from the leaves of Digitalis lanata. Lanatoside B exhibits anticancer activity against cholangiocarcinoma. | |||||||||||||||||||||
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References
- [1]. Zhang C, et al. Lanatoside C decelerates proliferation and induces apoptosis through inhibition of STAT3 and ROS-mediated mitochondrial membrane potential transformation in cholangiocarcinoma. Frontiers in pharmacology. 2023;14:1098915.
- [2]. Davydov VYa, et al. Correlation between the retention of cardiac glycosides in reversed-phase high-performance liquid chromatography with a diphenylsilyl stationary phase, the structure of their molecules and their biological activity. Journal of chromatography. 1982 Oct 15;248(1):49-62.
