175989-38-5
175989-38-5
Chemical Structure
Pixantrone hydrochloride
Synonym(s): BBR 2778 hydrochloride
- CAS No.: 175989-38-5
- Formula:C17H20ClN5O2
- Molecular Weight:361.83
IUPAC Name: 6,9-bis((2-aminoethyl)amino)benzo[g]isoquinoline-5,10-dione hydrochloride
InChIKey: NXSHYUUREPUCRN-UHFFFAOYSA-N
SMILES: O=C(C1=C(NCCN)C=CC(NCCN)=C12)C3=C(C=NC=C3)C2=O.Cl
Biological Activity: Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity[1][2].
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Pixantrone hydrochloride | Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. | |||||||||||||||||||||
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References
- [1]. Neil Beeharry, et al. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015;16(9):1397-406. [Content Brief]
- [2]. Brian B Hasinoff, et al. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. [Content Brief]
