176182-04-0
Chemical Structure
Polygalasaponin XXXII
- CAS No.: 176182-04-0
- Formula:C79H118O38
- Molecular Weight:1675.76
InChIKey: WZOBMHJVDKLZQM-YYYQSLJOSA-N
SMILES: OC[C@](C([C@]1([H])CC2(C)C)=CC[C@]3([H])[C@]4(C[C@@H]5O)C)(CC[C@]1(CC2)C(O[C@H](O[C@@H]6C)[C@@H]([C@H]([C@H]6OC(/C=C/C(C=C7)=CC=C7OC)=O)O[C@H](O[C@H]8C)[C@@H]([C@@H]([C@H]8O)O)O)O[C@H](O[C@H]9C)[C@@H]([C@@H]([C@H]9O[C@H](OC[C@H]%10O)[C@@H]([C@H]%10O[C@H](OC[C@@H]%11O)[C@@H]([C@H]%11O)O)O)O[C@H](OC[C@](O)%12CO)[C@@H]%12O)O)=O)[C@@]3(CC[C@@]4([H])[C@@](C)([C@H]5O[C@@H]([C@@H]([C@H]%13O)O)O[C@@H]([C@H]%13O)CO)C(O)=O)C
Biological Activity: Polygalasaponin XXXII is an orally active cognitive enhancer. Polygalasaponin XXXII promotes the phosphorylation of ERK, CREB, Synapsin I and TrkB. Polygalasaponin XXXII enhances basal synaptic transmission. Polygalasaponin XXXII attenuates Scopolamine (HY-N0296)-induced cognitive impairment and improves hippocampus-dependent learning and memory abilities. Polygalasaponin XXXII can be used in research related to cognitive dysfunction[1][2][3].
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Polygalasaponin XXXII | Polygalasaponin XXXII is an orally active cognitive enhancer. Polygalasaponin XXXII promotes the phosphorylation of ERK, CREB, Synapsin I and TrkB. Polygalasaponin XXXII enhances basal synaptic transmission. Polygalasaponin XXXII attenuates Scopolamine (HY-N0296)-induced cognitive impairment and improves hippocampus-dependent learning and memory abilities. Polygalasaponin XXXII can be used in research related to cognitive dysfunction. | |||||||||||||||||||||
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References
- [1]. Xue W, et al. Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory. Acta Pharmacol Sin. 2009 Sep;30(9):1211-9. [Content Brief]
- [2]. Zhang D, et al. Five new triterpene saponins, polygalasaponins XXVIII-XXXII from the root of Polygala japonica Houtt. Chem Pharm Bull (Tokyo). 1996 Apr;44(4):810-5. [Content Brief]
- [3]. Zhou H, et al. Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice. Acta Pharmacol Sin. 2016 Aug;37(8):1045-53. [Content Brief]
