17680-99-8
Chemical Structure
p-Cresol glucuronide
- CAS No.: 17680-99-8
- Formula:C13H16O7
- Molecular Weight:284.26
IUPAC Name: ammonium (2S,4S,5R,6R)-5-acetamido-4-hydroxy-2-(4-nitrophenoxy)-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate
InChIKey: JPAUCQAJHLSMQW-XPORZQOISA-N
SMILES: CC1=CC=C(C=C1)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C(=O)O)O)O)O
Biological Activity: p-Cresol glucuronide is a metabolite of p-Cresol (HY-Y0506). p-Cresol glucuronide acts as a TLR4-antagonizing blood-brain barrier protective agent in brain microvascular endothelial cells, and serves as a non-invasive urinary biomarker metabolite in renal cell carcinoma. p-Cresol glucuronide inhibits LPS (HY-D1056)-induced increase in blood-brain barrier permeability and signal response, impairs mitochondrial function, induces oxidative stress and enhances inflammatory responses, depletes intracellular glutathione, and increases cell necrosis. p-Cresol glucuronide can be used in studies related to renal cell carcinoma, chronic kidney disease and heart disease[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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p-Cresol glucuronide | 99.90% | p-Cresol glucuronide is a metabolite of p-Cresol (HY-Y0506). p-Cresol glucuronide acts as a TLR4-antagonizing blood-brain barrier protective agent in brain microvascular endothelial cells, and serves as a non-invasive urinary biomarker metabolite in renal cell carcinoma. p-Cresol glucuronide inhibits LPS (HY-D1056)-induced increase in blood-brain barrier permeability and signal response, impairs mitochondrial function, induces oxidative stress and enhances inflammatory responses, depletes intracellular glutathione, and increases cell necrosis. p-Cresol glucuronide can be used in studies related to renal cell carcinoma, chronic kidney disease and heart disease. | ||||||||||||||||||||
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Acetaminophen glucuronide (Standard) | ≥98% | Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor. | ||||||||||||||||||||
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Phenyl-β-D-glucuronide | 99.78% | Phenyl-β-D-glucuronide (Phenyl-Beta-D-Glucuronide) is a biochemical assay reagent. | ||||||||||||||||||||
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4-(β-D-glucopyranosyloxy)benzoic acid | 99.71% | 4-(β-D-glucopyranosyloxy)benzoic acid is a phenolic glucoside can be isolated from fennel seeds. | ||||||||||||||||||||
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Pseudolaroside A | Pseudolaroside A is a benzylisoquinoline glycoside that can be isolated from Pseudolarix kaempferi. | |||||||||||||||||||||
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m-Tolyl-β-D-glucopyranosiduronic acid | m-Tolyl-β-D-glucopyranosiduronic acid (m-Cresylglucuronide) is the glucuronide conjugate metabolite of m-Cresol (HY-Y0968), which is biosynthesized and isolated from rat urine. m-Tolyl-β-D-glucopyranosiduronic acid can be hydrolyzed by β-glucuronidase to release m-Cresol. | |||||||||||||||||||||
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Picein (Standard) | ≥98% | Picein (Standard) is the analytical standard of Picein. This product is intended for research and analytical applications. Picein, isolated from Picrorhiza kurroa, is a naturally occurring antioxidant. | ||||||||||||||||||||
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4-Nitrophenyl β-D-glucuronide | 99.87% | 4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for β-glucuronidase. | ||||||||||||||||||||
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4-Nitrophenyl α-D-Glucuronide | 4-Nitrophenyl α-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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2-Aminophenyl β-D-glucuronide | 2-Aminophenyl β-D-glucuronide is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology. | |||||||||||||||||||||
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4-Aminophenyl β-D-glucuronide | 95.08% | 4-Aminophenyl β-D-glucuronide is a biochemical reagent. | ||||||||||||||||||||
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References
- [1]. Stachulski AV, et al. A host-gut microbial amino acid co-metabolite, -cresol glucuronide, promotes blood-brain barrier integrity . Tissue barriers. 2023 Jan 02;11(1):2073175.
- [2]. Oto J, et al. Validation of urine p-cresol glucuronide as renal cell carcinoma non-invasive biomarker. Journal of proteomics. 2025 Jan 16;311:105357.
- [3]. Zhu S, et al. Effects of -Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of -Cresol Glucuronide Formation. Pharmaceutics. 2021 Jun 09;13(6):857.
